The synthesis of multi-substituted dibenzo [b,d]furan derivatives 7a-b and 11a-b from readily available starting materials is described. These compounds are important intermediates for synthesis of molecules having wide therapeutic applications.

Various 1,3‐dimethyl and 1‐methyl‐3‐phenylfuro[3,4‐c]coumarins (5a‐h and 6a‐h) have been synthesized by demethylation cyclization of the respective 3‐aryl‐4‐ethoxycarbonyl furans (3a‐h and 4a‐h). These ethoxycarbonyl furans were prepared by reacting appropriate 1‐aryl‐2‐nitro‐prop‐1‐ene (1a‐h) with ethyl acetoacetate or ethyl benzoylacetate under Nef reaction condition.

OMe CHO R O O O R' Me R 3 steps Various 1,3-dimethyl and 1-methyl-3-phenylfuro[3,4-c]coumarins (5a-h and 6a-h) have been synthesized by demethylation cyclization of the respective 3-aryl-4-ethoxycarbonyl furans (3a-h and 4a-h). These ethoxycarbonyl furans were prepared by reacting appropriate 1-aryl-2-nitro-prop-1-ene (1a-h) with ethyl acetoacetate or ethyl benzoylacetate under Nef reaction condition.

Synthesis of 3-(6-Aryl-pyridin-2-yl)-and 8-(6-Aryl-pyridin-2-yl) Coumarins -[via reaction of Mannich bases derived from acetylcoumarins with pyridinium salts (II) under Kroehnke-type reaction conditions]. -(BRAHMBHATT*, D. I.; GAJERA, J. M.; PANDYA, V. P.; PATEL, M. A.; Indian J.

We have developed a novel and one-pot synthesis of 6-arylpyrimidine-4-ol by reacting commercially available alkyl 3-oxo-3-arylpropanoate with formamide in the presence of stoichiometric amount of ammonium acetate.