Osteoporosis, a systemic bone disease, is characterized by decreased bone density due to various reasons, destructed bone microstructure, and increased bone fragility. The incidence of osteoporosis is very high among the elderly, and patients with osteoporosis are prone to suffer from spine fractures and hip fractures, which cause great harm to patients. Meanwhile, osteoporosis is mainly treated with anti-osteoporosis drugs that have side effects. Therefore, the development of new treatment modalities has a significant clinical impact. Sympathetic nerves play an important role in various physiological activities and the regulation of osteoporosis as well. Therefore, the role of sympathetic nerves in osteoporosis was reviewed, aiming to provide information for future targeting of sympathetic nerves in osteoporosis.

Review question / Objective: Aiming to provide information for future use of targeting sympathetic nerves in osteoporosis. Condition being studied: Osteoporosis. Eligibility criteria: We included only publications published in English and selected those findings that were, in our opinion, the most important. we further analyzed these articles, we mainly selected papers from the past 5 years, but also include well-respected older publications. INPLASY registration number:This protocol was registered with the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on 19 December 2022 and was last updated on 19 December 2022 (registration number INPLASY2022120079).