The chemical compound known as benzimidazole has been assigned to the category of heterocyclic aromatic in one of the potential classifications for it. This structure has a notable pharmacophore position in the scientific discipline of medicinal chemistry and enjoys a privileged status within that discipline. As a result of the fact that it possesses a wide range of beneficial therapeutic effects, such as those of antiulcerants, antihypertensives, analgesics, edicines, antivirals, antifungals, anticancer, and antihistamines, it serves a very important purpose. This is due to the fact that it has a very important purpose. The literature review reveals that benzimidazole derivatives are effective chemicals, and a wide range of reviews that are currently available on the market for organic chemistry and medical specialist studies have confirmed that the molecules of these compounds are helpful against a variety of different microorganisms. The importance of the methodology used in its synthesis has piqued the curiosity of synthetic organic chemists, who have shown an interest in the processes involved. As a direct result of this, we have made an effort in our evaluation of the gift to assemble information on the chemistry that lies behind a wide variety of substituted benzimidazole byproducts and the many medicinal applications of these substances.

Aim: The objective of this study was to assess the Anti-ulcer Activity of the Polyherbal Formulation made from the seeds of Cumin Cyminum, Trigonella Foenum Graecum, Piper Nigrum L. and rhizomes of Curcuma Longa in Wistar albino rats. Methods: Male Albino Rat of Wistar strain were used to evaluate the Polyherbal Formulation’s anti-ulcer properties utilising an ethanol-induced gastric ulcer model. The effectiveness of PHF was assessed by determining, gastric pH and gastric mucus, GSH, malondialdehyde (MDA), and nitric oxide (NO) levels in stomach tissues. Results: The administration of the 400 mg/kg dosage of polyherbal formulation significantly exhibits the gastroprotective effects, when compared to the ethanol group. Conclusion: PHF, containing seeds extracts of Cumin Cyminum, Trigonella Foenum Graecum, Piper Nigrum L. and rhizomes of Curcuma Longa was found to possess antiulcer properties in ethanol induced experimental animal models of gastric ulcers, and these findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity.

Oxadiazoles are a kind of heterocyclic molecule that can be identified by their five-membered ring structure, two azo groups, and a single oxygen atom in their make-up. These characteristics allow them to be distinguished from other heterocyclic compounds. Because of these features, it is possible to differentiate them from several other heterocyclic compounds. They have the highest importance and relevance in the area of heterocyclic chemistry, which is also where they have the most value. They are of the biggest significance. Research is being conducted on it in substantial amounts due to the fact that it has the potential to function as a starting point for the synthesis of bioactive molecules that are beneficial to the body. This article provides a brief discussion of the physicochemical features of oxadiazole, including its spectra and a few examples of how it may be synthesised. The article can be found here. The pharmacological effects of oxadiazole derivatives were investigated by our team of researchers, and the findings indicated that these compounds had a number of positive benefits, including anti-inflammatory, anti-cancer, anti-fungal, anti-osteoporotic, and anti-microbial properties. In this piece, we will have a brief discussion on both synthetic and naturally occurring medications that include the oxadiazole ring in addition to the moiety. This talk will focus on pharmaceuticals that have been manufactured. The production of these compounds may take place in a laboratory, or they may be found occurring naturally in their natural environments.