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The recent availability of low-cost wearable continuous wave (cw) fNIRS/DOT devices is supposed to revolutionize cortical human brain mapping in the real-life. Ecological paper-pencil tests, as the Trail Making Test (TMT), are commonly used in neuropsychological clinics but its neural substrates are not completely understood. The aim of this study was to map, using a new cw wearable fNIRS/DOT imager (NIRSIT), the prefrontal cortex (PFC) hemodynamic response in healthy subjects while performing the TMT. The ANOVA analysis, performed on the 60 region-DOT data, shows a significant task-related activation of the PFC. These preliminary results support the validity of this wearable technology to provide online high-density PFC activation maps.

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