The KALLISTO project aims at finding cost-efficient sets of measures to meet the Water Framework Directive (WFD) derived goals for the Dommel River (The Netherlands). An integrated model, which showed to be a powerful tool to analyze the interactions within the integrated urban wastewater system, was first used to evaluate measures in the urban wastewater system using the existing infrastructure and new RTC strategies. As the latter resulted to be beneficial but not sufficient, this contribution investigates the potential benefit of additional infrastructural measures to improve the system cost-effectively and have it meet the WFD goals and this using an integrated perspective. Finally, a scenario analysis was conducted to investigate the impact of uncertainty in the main model assumptions and model parameters on the performance robustness of the selected set of measures. Apart from some extreme worst-case scenarios, the proposed set of measures turned out to be sufficiently robust and significantly more cost-effective compared to using a more traditional non-integrated approach.