How to cite this article: Buonomo A, Pucci S, De Pasquale TMA. Localized delayed-type hypersensitivity of face and lips from alprazolam and cross-reactivity with other benzodiazepines.

We report the case of a 74-year-old man who was immunosuppressed and presented with multiple skin lesions on the right upper limb. Histological examination revealed epidermal pseudocarcinomatous hyperplasia and dermal granulomatous suppurative infiltrate with aggregates of Gram-positive microorganisms compatible with a grain-forming infection.