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Case: A 58-year-old man with rheumatoid arthritis (RA) on disease modifying antirheumatic drug therapy presented with chronic right shoulder pain. Magnetic resonance imaging was concerning for rice body disease which was confirmed through histology after intraoperative deltoid bursa resection. Conclusions: Rice bodies can develop regardless of RA symptom severity or the degree of RA medical therapy administered. Therefore, physicians should not disregard rice bodies as a possible cause of symptoms in individuals on appropriate RA medical therapy or who are demonstrating adequate RA symptom and flair control.

Harris, Biophys. Soc. abstracts, 2012). To determine directly whether cMyBP-C binding affects tropomyosin position, we carried out 3D reconstruction of negatively stained thin filaments (containing F-actin, tropomyosin and troponin) decorated with the N-terminal fragment containing domains C0 to C2. Clear decoration was obtained under a variety of salt conditions. 3D reconstructions suggest that under most conditions cMyBP-C does not displace tropomyosin from its low Ca 2þ position, although under certain conditions some shift of tropomyosin did appear to occur. At high Ca 2þ , there was little effect on tropomyosin position. The results suggest that cMyBP-C may modulate thin filament function by physically competing with tropomyosin for its low Ca 2þ site on Factin.

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