Introduction:Iliopsoas abscess (IPA) is the collection of pus in the iliopsoas compartment. The etiology of IPA is variable and depends on the geographical area and the antibiotic usage prevalence in that area. This study attempts to evaluate the etiology, clinical features, risk factors, management modalities, and outcomes in patients with IPA from a tertiary care center in South India.Materials and Methods:This was a retrospective study done in a tertiary care center in South India. Patient details were obtained from electronic medical records.Results:A total of 43 patients were enrolled in the study, the causative organism could be identified in 20 (46.5%) patients. The most common etiology was tuberculosis (TB). Most (23 [56.5%]) patients were treated conservatively, 20 (46.5%) patients were treated with percutaneous drainage (PCD), and 2 (4%) patients required surgery.Conclusion:The most common cause of IPA is TB. PCD was successful in 95% of the patients with complete resolution of symptoms.