SUMMARY OBJECTIVES Lymphomas are a heterogeneous set of malignant neoplasias of lymphoid B and NK/T mature and immature cells at various stages of differentiation. Genetic and molecular biology tools are used to appropriately classify the type and prognosis of the lymphomas, which have implications in therapeutic effectiveness. Among them, the nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) oxidase (NOX5) enzymes have been explored. This study analyzed the expression of NADPH oxidase 5 in lymphoma tissue according to the degree of tumor aggressiveness. METHODS Slides from 64 patients with lymphoma who had paraffin-embedded tissue available were reviewed by two independent, experienced pathologists. They classified tumors according to the WHO classification (2017). NOX5 expression in tissues was assessed by immunohistochemical staining using a tissue microarray. The assay was interpreted using a scoring system of 0, 1, 2, and 3, for cytoplasmic staining of NOX5 corresponding to negative, weak, intermediate, and strong staining, respectively. We compared the expression of NOX5 in patients with aggressive versus non-aggressive lymphomas. RESULTS NOX5 expression was positive in 100% (27/27) of aggressive lymphomas and in 19% (7/37) of non-aggressive ones. The seven patients with positive expression of NOX5 presented intermediate staining (2); strong staining (3) was observed only in tissues of aggressive lymphomas, and negative and weak staining (0 and 1) were observed only in non-aggressive lymphomas. CONCLUSIONS Aggressive lymphomas overexpress NOX5 protein. The higher NOX5 expression in aggressive lymphomas can suggest an involvement of this enzyme on the acquisition of an aggressive phenotype in lymphoid neoplasia.

Este artigo vem mostrar como a Assistência Farmacêutica é inserida dentro do Sistema Único de Saúde ( SUS ) . Mostrando sua importância e promovendo ampla inclusão social, a igualdade no atendimento e a globalização das ações e serviços de saúde. Foi incorporada ao SUS uma inovação tecnológica em 2009 um sistema de informações para a Assistência Farmacêutica do Sistema Único de Saúde chamada Hórus . Com o objetivo de qualificação, monitorando e avaliando as ações da Assistência Farmacêutica no país e contribuindo para o planejamento dos serviços. Nas três décadas do SUS são associados avanços e regresso considerando a complexidade nacional e suas mudanças. As atividades do farmacêutico foram avaliadas em relação à organização do serviço, melhorando a prescrição médica e elaborando orientações nos serviços farmacêuticos clínicos. O crescimento do acesso da população no SUS exigiu mudanças nas distribuições de medicamentos, aumentando a cobertura e minimizando os custos.