A simple procedure was developed with the adsorption of the compounds estrone (E1), 17α-ethinylestradiol (EE2), and sulfamethoxazole (SMX) in aqueous solutions using banana peel as an adsorbent material. Adsorbent mass, contact time, and granulometry were studied through multivariate design. The proposed adsorbent was advantageous, with removal exceeding 80% for E1 and EE2 and 70% for SMX in the analysed samples. Studies of adsorption isotherms demonstrate adequacy compared to the Freundlich model, and kinetic studies indicate adsorption through the pseudosecond order model (E1 = 0.9999, EE2 = 0.9999, and SMX = 0.9999). The developed method was successfully applied in supply water samples and accuracy was evaluated through recovery tests, with recovery ranging from 70% to 96%.