The Buschke-Lowenstein tumor (TBL) or giant condyloma acuminata (GAG) is a tumor of viral origin with predominantly sexual transmission. A rare nosological entity 0.1%. Affecting men in 80% of cases and developing on the sexual organs perineum in women, the manifestation is in about 90% on the vulva. The contributing factors are the multiplicity of sexual partners, repeated infections, and decline in humanity. The condition phase is characterized by a cauliflower or rooster's crest tumor. Treatment is primarily surgical, followed by clinical and histological monitoring. We report a clinical case of giant condyloma acuminata at the Military Hospital of Instruction Mohamed V Rabat from 01/15/2021 TO 01/22/2021, the patient is operated with favorable outcome: seen on D 30 post-op.