tonated ethyl glycinate (11.8 kcal mol-1),25 ethyl acetate (11.4 kcal mol-1),28 and Et3N+CH2C02Et (12.7 kcal mol-1).29 The large increase in rate observed for the chelated ester results entirely from the large positive entropy of activation (--5 cal mol-1 deg-1). The above hydrolysis reactions are all associated with nega-(28) E.
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