A sustainable synthesis of 5-fluoromethyl-2-oxazoles by use of electrochemistry has been demonstrated. Hypervalent ArIF 2 is generated by direct electrochemical oxidation of iodoarene ArI in Et 3 N•5HF and mediates the fluorocyclization of N-propargylamides to 5-fluoromethyl-2-oxazoles. The stoichiometry in ArI turned out to be a key parameter in controlling the product selectivity. This electrochemical protocol provides access to fluorinated oxazoles starting from simply available N-propargylamides with yields up to 65% and offers a green alternative over conventional reagent-based approaches.

Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers.

A novel and scalable protocol for the synthesis of para-benzoquinones from inexpensive phenols is reported. In advancement of previous methods the oxidation is performed free of catalyst, mediator or terminal...