Background: Altered Cl -homeostasis and GABAergic function are associated with nociceptive input hypersensitivity. This study investigated the role of two major intracellular Cl -regulatory proteins, Na + -K + -Cl -cotransporter 1 (NKCC1) and K + -Cl -cotransporter 2 (KCC2), in neuropathic pain following spinal cord injury (SCI).
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