Treatment with USCDT using a shorter delivery duration and lower-dose tPA was associated with improved right ventricular function and reduced clot burden compared with baseline. The major bleeding rate was low, but 1 intracranial hemorrhage event due to tPA delivered by USCDT did occur.

Elevation of free cytoplasmic calcium is the common pathway of platelet activation, leading to shape change, shedding of platelet microparticles (PMP), aggregation, and secretion of internal granules, including expression of CD62p on the surface. Platelet activation is well documented in unstable angina (UA) and acute myocardial infarction (MI). We investigated the following markers of platelet activation in 55 patients undergoing coronary angiography for suspected CAD: free cytoplasmic calcium, [Ca Key words: platelet microparticles; calcium homeostasis; immune thrombocytopenic purpura (ITP); myocardial infarction; unstable angina drome, a rare congenital bleeding disorder, a defect in INTRODUCTION platelet procoagulant activity is believed to underlie the There is ample evidence that coronary thrombosis oc-hemorrhagic tendency and has been attributed to a defect curs in patients with acute myocardial infarction (MI) and unstable angina (UA) [1], and that platelet activation plays a central role in the thrombogenesis of coronary clotting near the site of activation [6][7][8][9]. In Scott's syn-ᮊ 1997 Wiley-Liss, Inc.

By including methods usually found in RCT, ARRIVE 1 captured a broad spectrum of disease treated in standard practice with high levels of ascertainment of clinical outcomes. In the more complicated cases, expectedly higher adverse event rates were seen compared to that found in the simple-use cases or pivotal RCT. These results have now been included in the Directions for Use, to aid in physician and patient decision-making.

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