John R. Nichols scite author profile

Selective breeding produced two strains of rats that differ in their susceptibility to morphine addiction. Inbreeding the more susceptible rats in an unselected population produced susceptible offspring; inbreeding resistant rats produced resistant offspring. Further selection and inbreeding increased the strain difference in the F(2) and F(3) generations. The F(3) generation also differed in their susceptibility to alcohol addiction.

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Apparatus and technique involved in a laboratory method of detecting the addictiveness of drugs

Headlee

Coppock

Nichols

1955

Journal of the American Pharmaceutical Association (Scientific

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John R. Nichols

How Opiates Change Behavior

Annulation of dihydroimidazoles: a 1,3-dipolar cycloaddition route to pyrrolo[1,2-a]imidazoles, pyrrolidines and pyrroles

Addiction Liability of Albino Rats: Breeding for Quantitative Differences in Morphine Drinking

Apparatus and technique involved in a laboratory method of detecting the addictiveness of drugs

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