The vast majority of human lymphoid neoplasms examined to date have been associated with a proliferation of bone marrow-dependent (B) lymphocytes. In an effort to delineate human tumors of T-cell (thymusdependent) lineage, use was made of the peripheral blood leukocytes of sixteen subjects with various forms of mycosis fungoides. The abnormal cells in the circulation of these patients are morphologically identical to those that infiltrate their nodes and skin. On electron microscopy, such neoplastic lymphocytes (S6zary cells) had "cerebriform" nuclei and an abundance of cytoplasmic fibrils not described heretofore. S6zary cells were nonadherent and nonphagocytic and usually responded to stimulation with phytohemagglutinin, refuting earlier suggestions that the cells represent monocytes or histiocytes. In contrast to chronic lymphocytic leukemia lymphocytes, the Szary cells lacked surface immunoglobulin and receptors for complement. Ultrastructural analysis identified S6zary cells in the center of directly formed rosettes (E-rosettes) characterizing the behavior of T lymphocytes in this test.Though some S6zary cells lacked both T and B cell-surface properties, in general, these observations support the view that the S6zary cell is a neoplastic variant of a thymusderived lymphocyte.

The thirty-fourth case of multicentric reticulohistiocytosis with skin nodules and arthritis exhibiting typical histiocytic infiltrates in skin and synovium in a 16-year-old white female high school school student is presented. Unlike the usual reported course of this disease, the arthritis is currently of moderate degree and has been only slowly progressive. A brief review of the major manifestations of this disorder is given.Multicentric reticulohistiocytosis is a rare systemic disorder of unknown etiology manifested by the development of nodules containing infiltrates of characteristic histiocytic and multinucleated giant cells in synovium, skin, subcutaneous tissues and occasionally bone and other tissues. T h e hallmarks of the disease are arthritis which may be of a severe mutilating type, associated with skin and mucosal lesions which may become disfiguring, especially in the face. Although over a dozen names have been proposed, multicentric reticulohistiocytosis (MR) and the term lipoid dermotoarthritis have found the widest acceptance, the former becoming the more accepted of the two.In a recent critical review of the world literature, Barrow and Holubar (1) assembled a total of 33 cases of this disorder which met the criteria of both arthritis and skin lesions, though they noted that there were probably

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