Word Count: 198 Text Word Count: 4875Abstract Campylobacter jejuni is a leading cause of foodborne infection due to its ability to asymptomatically colonize agricultural animals. In addition to its prevalence, Campylobacter is becoming increasingly resistant to the clinical antibiotics, azithromycin and ciprofloxacin. As a result, public health agencies have identified drug resistantCampylobacter as a serious threat to public health and have suggested combating the pathogen at the farm-level by reducing its burden within agricultural animal reservoirs.isolating bacteriophage that infect C. jejuni from various environmental sources. In previous studies, bacteriophage that kill C. jejuni have been isolated from sewage and pig manure; however, the majority have been isolated from chickens, and have been relatively few in number. We postulate this study increases the likelihood of isolating bacteriophage efficacious at combating C. jejuni colonization of agricultural animal hosts at the farm-level or treating infected humans.

International efforts to curb antimicrobial resistance have focused on drug development and limiting unnecessary use. However, in areas where water, sanitation, and hygiene infrastructure is lacking, and where biosecurity in food-animal production is poor, pathogen-flow between humans and animals could exacerbate the emergence and spread of resistant pathogens. Here, we compared mobile resistance elements among Escherichia coli recovered from humans and meat in Cambodia, a country with substantial connectivity between humans and animals, unregulated antibiotic use, and poor environmental controls. We identified multiple resistance-encoding plasmids and a novel, blaCTX-M and qnrS1-encoding transposon that were widely dispersed in both humans and animals, a phenomenon rarely observed in high-income settings. Our findings indicate that plugging leaks at human-animal interfaces should be a critical part of addressing antimicrobial resistance in low and middle-income countries.