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A generic approach to chiral separations using capillary electrophoresis is outlined. The generic method was developed by investigating the interactions of Ž . charged sulfobutyl ether-␤-cyclodextrin, SBE-␤-CD and neutral cyclodextrins Ž . Ž primarily ␥and dimethyl-␤-cyclodextrin in a low pH buffer 50 mM sodium . Ž . dihydrogen phosphate, pH 2.5 . Using a background electrolyte BGE containing Ž . 5% wrw SBE-␤-CD, 25 mM ␥-cyclodextrin ␥-CD and 25 mM dimethyl-␤-CD Ž . DM-␤-CD dissolved in the phosphate buffer, resolution of more than 90% of the 26 randomly selected racemic pharmaceutical drugs or their synthetic intermediates was achieved.

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