This paper presents the exible containership loading problem for seaport container terminals. The integrated management of loading operations, planning of the transport vehicles to use and their scheduling is what we dene as the Flexible Ship Loading Problem (FSLP). The exibility comes from a cooperative agreement between the terminal operator and the liner shipping company, specifying that the terminal has the right to decide which specic container to load for each slot obeying the class-based stowage plan received from the liner. We formulate a mathematical model for the problem. Then we present various modelling enhancements and a mathematical model to obtain strong lower bounds. We also propose a heuristic algorithm to solve the problem. It is shown that enhancements improve the performance of formulation signicantly, and the heuristic eciently generates high-quality solutions. Results also point out that substantial cost savings can be achieved by integrating the ship loading operations.

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The present study aimed at evaluating the effects of daily repeated exposures to low cobalt or chromate concentrations on the hands of patients with hand eczema and cobalt or chromate allergy. For 2 weeks, the patients immersed a finger for 10 min daily into the appropriate metal salt solution in water. During the 1st week, this was a 10 or 50 mg/l cobalt concentration or a 10 mg/l chromate concentration, and, during the 2nd week, a 100 or 200 mg/l cobalt concentration or a 100 mg/l chromate concentration. This regimen elicited a flare of hand eczema only in the chromate-exposed chromate-sensitive patients. During the exposure period, accumulation of cobalt or chromate in the nail was demonstrated. Standardization of chemical methods of quantification of skin exposure to allergens, combined with experimental exposure studies in patients with specific contact allergy, will increase the possibility of providing evidence-based medicine in the area of allergic contact dermatitis in the future.

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