Prescribing the proper resistance training (RT) program is critical to optimize skeletal muscle hypertrophy and strength. Periodization is a strategy that entails planned manipulations of training variables to maximize fitness adaptations while minimizing the risk of overtraining. Multiple meta-analyses have shown periodized RT to be superior to non-periodized RT for enhancing muscular strength. These findings are consistent irrespective of training status or training volume. Both the linear model and the undulating model are effective for enhancing strength, although a greater benefit might be achieved through the undulating model. Despite the suggested superiority of periodized RT for strength development, some authors suggest that this might be a consequence of the study designs employed rather than the nature of periodized training. In addition, several limitations exist in the periodization literature, making it difficult to accurately assess the efficacy of periodized RT. With regard to enhancing skeletal muscle hypertrophy, both the undulating model and the linear model appear equally effective; however, this conclusion can only be generalized to untrained populations. When comparing periodized RT to non-periodized RT programs, the research is unclear on whether periodized RT is necessary to maximize skeletal muscle hypertrophy.