Cryotherapy reduced the incidence of postoperative pain and the need for medication intake in patients presenting with a diagnosis of necrotic pulp and symptomatic apical periodontitis.

Some placebo-controlled trials can continue ethically after a candidate vaccine is found to be safe and efficacious

No abstract

Highlights Quickly finding a safe and effective vaccine against SARS Co-V-2 would be of great value. Collecting rigorous safety and efficacy data without compromising ethical and scientific norms is critical. The best approach is accelerated individually randomized controlled trials. Premature distribution could hamper public health and finding safe, effective SARS CoV-2 vaccines.

No abstract