Highlights d Neutrophil aging is an intrinsically driven, bona fide circadian process d Bmal1 and CXCR2 induce neutrophil aging, whereas CXCR4 antagonizes it d Diurnal aging critically dictates how and when neutrophils migrate into tissues d Aging favors neutrophil clearance, thereby protecting the cardiovascular system

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Our experience suggests that 1000 mg rituximab single infusion on demand is a reasonable schedule for long-term treatment of those patients with good response after the first cycles, especially in seropositive patients and when it is applied as a first- or second-line biological therapy.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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