The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

No abstract

Cephalexin is a new semisynthetic cephalosporin C derivative, which is well absorbed from the gastrointestinal tract and excreted in high concentration in the urine. Even in patients with impaired renal function, the concentrations of cephalexin present in the urine are adequate for the treatment of most urinary tract infections produced by Escherichia coli, Klebsiella, and Proteus mirabilis. In anephric patients, single doses of 250 or 500 mg of cephalexin resulted in high, prolonged serum concentrations. Peak levels were usually observed within 1 hr. However, in two of six anephric patients, peak levels were reached after 6 and 12 hr due to delayed absorption. Hemodialysis for 6 hr reduced the serum concentration of cephalexin by 58%c.