Urban dust is a mixture of deposited particles from different sources usually linked to potentially toxic elements (PTEs). Despite the industrialization of many South American countries, little is known about the impact of particulate matter in large cities; these data are necessary to promote environmental policies aiming to protect human health. The main objective of this work was to evaluate the particle size distribution, composition, and environmental and human health risks of settled dust particles from Barranquilla, a Colombian Caribbean industrialized area. Trace elements were analyzed by inductively coupled plasma-mass spectrometry from 35 different sites, covering all city areas. Dust was mostly composed of 10-to-70-μm particles. The average concentrations of V,