Objective: To assess the temporal trends of hospitalizations for pulmonary embolism (PE) in Brazil, its regions, and states between 2008 and 2019. Methods: An ecological and time series study was conducted. Data were obtained from the Hospital Information System (SIH) of the Brazilian Ministry of Health. The inflection point regression model was applied for temporal trend analyses. Trends were classified as increasing, decreasing, or stationary according to the slope of the regression line. The Annual Percent Charge (APC) and the Average Annual Percent Change (AAPC) were calculated considering a confidence interval of 95% and p-value <0.05. Furthermore, spatial distribution maps of epidemiological indicators related to PE in Brazil were elaborated. Results: There was an increasing trend in the hospitalization rate for PE in Brazil, ranging from 2.57 in 2008 to 4.44/100,000 in 2019 (AAPC=5.6%; p<0.001). Total and average hospitalizations costs also showed increasing trend in the country (AAPC=9.2% and 3.0%, respectively). Still, there was a decrease in the in-hospital mortality rate (from 21.21% to 17.11%; AAPC=-1.9%; p<0.001). Similar trends were observed in most regions. The average hospitalization time in Brazil showed a stationary trend. The hospitalization rate has also increased in 18 states (66.67%). Seven states showed a decrease in the mortality rate (25.93%), except for Roraima, which showed an increasing trend. Conclusion: Hospitalizations for PE represent a serious public health problem in Brazil and the temporal patterns observed herein demonstrate an increasing trend in all regions and states of the country. Keywords: Pulmonary embolism; Epidemiology; Ecological studies; Time series.

This is a systematic review with the aim of analyzing the role of 5-HT2A receptors in hippocampal-dependent memory. In order to do this, we searched the PubMed, Science Direct, and Neuron databases between October 23 and 29, 2018, using the following descriptor combinations: memory, 5-HT2A, and hippocampus, present in the title, abstract, or keywords, with no restrictions on study date or language. Following search and selection, we analyzed risk of bias, and the results were subsequently synthesized according to the experimental model. Out of 40 articles, four were included in qualitative analysis. The data indicate that the 5-HT2A receptors in the hippocampus play an important role in the memory consolidation process, although they do not interfere in the encoding or retrieval processes of these memories. Additionally, chronic use of receptor agonists in models of Alzheimer's disease also demonstrates better performance in the object recognition tests. The action of 5-HT2A receptors has also been shown to be important to aversive memory formation, thus attributing a prominent role to these receptors in hippocampal-dependent memory processes.