Two sisters with 45,X Turner's Syndrome are described. A third and fourth sister as well as a brother, father and mother have normal phenotypes and karyotypes. To our knowledge this represents the only reported sibship in which two sisters have the 45,X karyotype.It is unlikely that these findings are the result of random errors in meiosis. Rather, the exact similarity of the sister's aneuploidy sug-

The existence of two distinct embryonic hemoglobins (Hb Gower-1 and Hb Gower-2) in young fetuses up to 85 mm crown-rump length has been well established. Persistence of Hb Gower-2 to (and for a short period after) birth associated with the trisomy D1 syndrome has been well documented. With rare exceptions, however, electrophoretic documentation of this hemoprotein was not accomplished in the majority of subsequently reported cases. Marked instability of Hb Gower-2, especially on cold storage has received but one mention in the literature. The purpose of this paper is to report a case of D/D translocation trisomy in which the demonstration of Hb Gower-2 would not have been possible without this knowledge.

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