Intraplate Iberia is a region of slow lithopsheric deformation (<1 mm/yr) with significant historical earthquake activity. Recent high‐quality instrumental data have shown that small‐magnitude earthquakes collapse along clusters and lineaments, which however do not bear a clear relationship to geologically mapped active structures. In this article, we investigate the controls of these earthquake clusters. In particular, we study two of the identified clusters—the Arraiolos and the Évora seismic zones (ASZ and ESZ), located in the Western Ossa Morena Zone, southwest Iberia. The ASZ marks a sharp boundary between a seismically active region to its south and a more quiet region to its north. We revise historical earthquakes in order to clarify whether earthquake activity in the region is persistent. We use data from a local network to compute accurate epicenters, focal depth, focal mechanisms, and spatiotemporal clustering, thus characterizing ongoing small‐scale fracturing. Finally, we analyze complementary data sets, including tomographic models, Global Navigation Satellite Systems data, magnetic anomalies, and gravity anomalies, in order to discuss the factors that control seismogenesis in the two seismic zones. Consistency between earthquake locations, focal mechanisms and Global Navigation Satellite Systems data suggests that the ASZ is an active right‐lateral shear zone, which divides two blocks within the Western Ossa Morena Zone. The ESZ seems to localize microseismicity due to its granitic lithology. These results suggest that high‐resolution geophysical data have the potential to reveal blocks with different seismogenic and rheological behaviors, which may be used to improve our understanding of fault systems and the assessment of earthquake hazard in slowly deforming regions.