No abstract

I and II plasma concentrat ions in age-matched (M±ES: CA t t .29±0.38 and 11.95±0.94, BA 9 97±0.55 and 9.95±0.93) pts presenting with TS and on the IGF-1 generation by fibrobla sts in cu ltu re from 3 TS pts and t control. IG F-11 plasma concentratio n was normal and unresponsive to the treatment. IGF-1 plasma basal concentration was normal and increased significantly in both groups afte r 12 mo nths of treatm ent. No difference was fou nd between the two treatment regimens. Furthermore, we verified th e abi lity of the fibrob lasts from TS pts to synthetize in vitro the IGF•I in basal and GH, EE or GH + EE stimulated conditions. The results indicate that TS fibroblasts produce less IGF•I than fibroblasts from control; this finding can account for a reduced paracrine/autocrine action of IGF-1 in these pts, in spite of a normal IGF-1 plasrna concentration. Addition of in creasing concentrations of GH (0•1 00 ng/ml of medium) induced a dose-dependent increase of IGF-1 in th e co nditioned medium with a maximum at 50 ng/ml of GH. Addition of EE (at 0-500 pg /m l of medium) also result ed in an incre ased production of IGF-1 with a maximum already at 25 pg/ml of EE. The combination of increasing do ses of GH with 50 pg/ml of EE was additive only in the fibroblasts from one pt.

Background: Hypothyroidism is an endocrine disorder that is seen much more commonly in females than in males. This could perhaps be due to factors that confer protection against the development of hypothyroidism in males. The male sex hormone testosterone would have protective action on the different systems, probably due to a mechanism of action which is complementary. Aims and Objective: To investigate the association between serum testosterone level, audiovisual reaction time, and working memory score in newly diagnosed hypothyroid and euthyroid men. Materials and Methods: This was a comparative study. 15 newly diagnosed hypothyroid males between 18 and 45 years of age, recruited from the Endocrinology Department of MS Ramaiah Medical College Hospital, Bangalore, and 15 euthyroid males were assessed for audiovisual reaction time, working memory, serum testosterone, T4, and serum thyroid hormones (TSH). Results: Independent t-test between hypothyroid and euthyroid groups revealed that there was statistically significant difference in group mean audio-visual reaction time, working memory, serum T4, and TSH levels (P < 0.05). Conclusion: Hypothyroid patients had longer audiovisual reaction time and the working memory scores were reduced. The serum T4 level was lower and serum TSH level was higher, but the serum testosterone level was not significantly different compared to euthyroid subjects.