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Condensation of 17/3-estradiol 3-benzyl ether (I) with 1 a-bromo-A-trifluoroacetamido tri-O-acetylglucopyranoside (Xb) in the presence of cadmium carbonate gave the corresponding 17/3-estradiol 17-(a-and /3-)glycosides (lib, III). Selective deacylation and reacetylation followed by debenzylation afforded the 17/3-estradiol 17-(a-and /3-)A-acetyl-T Xhe isolation of -estradiol 3-glucuronide 17/3-acetylglucosaminide from rabbit urine by Layne and coworkers (1964) revealed a new conjugating pathway for steroids. In a subsequent series of papers, Layne and coworkers (Jirku and Layne, 1965; Layne el al., 1965;Collins et al., 1967Collins et al., , 1968) studied C-l7-glucosaminide formation by the action of an A-acetylglucosaminyl-transfer enzyme system and showed that the stereochemical configuration of the Hahydroxyl group was a necessary structural feature for estrogens containing a C-3-glucuronide.Recently, other double conjugates containing a A-acetylglucosaminide grouping have been isolated from human urine.

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Common cause of death in demyelinating disorders such as Multiple sclerosis has been reported to be infections or cardiorespiratory causes. We report 2 patients who were being investigated for Multiple sclerosis and related disorders who had an unexpected sudden death. Our first case is a 26 year old who presented with Optic Neuritis and past history suggestive of Transverse Mellitus and our second case was a 30 year old woman presented with recurrent Optic Neuritis. They were both being assessed for demyelinating disorders and had sudden unexpected death. More research needs to be done to correlate death directly related to demyelinating diseases.