Author Contribution: JLF and BRZ performed the majority of the experimental work for this study. LWJ and JZ generated the original MNX founders for the mouse colonies. DRM, DGW, MJS, MJ, KJD, and BC assisted in the conduction experiments. WEB and CCW performed the TEM experiments. MP and XC provided assistance with MNX colony maintenance, haplotyping and breeding. TGS assisted JLF with the mtDNA sequencing experiments. RAK and LWJ assisted in the experimental design for developing the MNX model. LJD and VDU assisted in experimental design; DRW and SWB generated overall the experimental design. JLF, LJD, VDU, DRW and SWB wrote the manuscript.

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