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Labeled 2-aminoethyl [32P]phosphonate is incorporated into lipids of rat tissues. This incorporation, 48 h after an intraperitoneal injection, is maximum in the liver lipid (2.5O/, of the injected dose) and very small in the brain.After a second injection, 24 h later, urine excretion was about 40°/, of the first dose and only So/, of the second dose.The incorporation of aminoethyl [32P]phosphonate into lipids of liver subcellular fractions is maximum in fraction from centrifugation at 1000 x g for 10 min and similar for mitochondria and microsomes.Thin-layer chromatography was employed to demonstrate that aminoethyl [32P]phosphonate was incorporated into three lipids of the rat liver.The results show the formation of sphingophosphonolipids investigated after mild alkaline hydrolysis of liver lipids. I n addition, a low incorporation of aminoethyl [32P]phosphonate into lipids of rat liver homogenate was demonstrated. This incorporation was stimulated by the addition of CTP.

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