Currently, biological samples that are analyzed microscopically such as blood smears or tissue sections need to be stained to visualize important information such cell nuclei. This represents a major hurdle on the path to further automation, increases costs and can lead to significant lab-to-lab variation in terms of diagnostic results. Here, the authors will present a novel microscopy approach, based on UV Fourier Ptychography Microscopy, that is able to directly image blood smears and digital pathology samples without the need for staining.

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