Diabetes is non-communicable disorder that is often a result of change in lifestyle or genetic variations among individuals across the globe. Diabetes  is a fatal condition and it is an unpredictable disorder hence it is regarded  as a tragedy, painful, horrible and terrifying disorder. This is why this article is intended to call out readers, researchers and scientists to do whatever could be done to prevent, withstand, overcome or cure diabetes particularly type 2 which is mostly found widely. Although the cure of diabetes has not yet been found, the goal is to be able to alter diabetic patient perceptive about the disorder so that they can bear the disorder as a part of who they are bravely, instead of being affected by the disorder condition, and to gradually alert patient awareness will improve patient disorder state, tolerance and acceptance while science and technology are advancing to find the cure or vaccine. Since this chronic disorder have no cure or vaccine, the patient suffers a lot from not only health problems but also psychological, emotional and financial problems therefore it is essential to develop strength within diabetic patients to withstand the disorder state via treatment, surgery, yoga, meditation, exercise, nutrition and habitual changes. Elevating diabetic mellitus patient’s attitude, knowledge, self-acceptance and strength will result into better patient compliance toward the treatment but also society’s perceptive will be enhanced by care toward diabetic mellitus patients, through various seminars and Counselling.

Microsponges are those drug delivery systems which are intended in a way to deliver a minimum dose of the drug or pharmaceutically active ingredient to increase the stability of formulation, to alter drug release profile. Ketoconazole is an imidazole anti-fungal agent  belonging to BCS class II. The main objective of this research work is to formulate and evaluate ketoconazole microsponge for topical  delivery by using various polymers such eudragit S-100, eudragit L-100 in four ratios 1:2, 1:3, 1:4, 1:5 by quasi emulsion method. The  formulations prepared were labelled based on the ratios as ES 2. ES 3, ES 4, ES 5 for eudragit S-100 and EL 2, EL 3, EL 4, EL 5 for eudragit L-100. Evaluation tests like entrapment efficiency, production yield, drug content was performed and formulation of eudragit L-100 (EL 5) and eudragit S-100 (ES 5) showed better results. ES 5 and EL 5 formulations were optimized and tests like in vitro dissolution studies  were conducted which showed that the formulation ES 5 showed released upto 8 hours and can be used in the formulation of gel. The  gel (GES5) was prepared by usingmicrosponges containing the drug ketoconazole equivalent to 1 % w/w and was incorporated into  the gel base made up of Carbopol 934. The microsponges were sieved and were dispersed in Carbopol gel. Evaluation tests like pH  measurement, visual inspection, spreadability studies, drug content and in vitro diffusion studies. This method of formulating  microsponges has improved drug delivery therefore helping in the enhancement of the bioavailability of the drug and also acts as an efficient carrier through the skin.