IntroductionStudent‐run free clinics provide critical medical services to underserved populations. Pharmacy resident involvement in this setting is not thoroughly documented in the current literature.ObjectivesTo evaluate the progression of post‐graduate year one (PGY1) residents through a longitudinal experience in a medical student‐run free clinic by assessing the interventions made and to characterize the clinic practice and patient population.MethodsDatabases of pharmacist interventions, clinic demographics, and prescriptions were assessed from July 2016 through August 2018. The primary outcome was the frequency of each intervention type per subject‐visit made by PGY1 residents across quarterly segments (August‐October, November‐January, February‐April, and May‐June). Interventions were excluded if provided by a non‐PGY1 pharmacist or during the annual training period. Secondary outcomes included the proportion of advanced practice skill interventions and frequency of total interventions across quarterly segments.ResultsThere were 604 interventions (604/1056; 57.2%) included after applying exclusion criteria. Interventions most performed were medication therapy recommendation (209/604; 34.6%) and prescription facilitation (201/604; 33.3%). There was no statistically significant difference amongst the quarters for any individual intervention type (all P > .05). This held true for total interventions (P = .115). There was an association identified between time and delivery of advanced interventions per subject‐visit (P = .004), with higher rates identified in the second and third quarters (P = .508 and .448, respectively) compared with the first and fourth quarters (P = 0.327 and 0.333, respectively). The diseases with the most interventions by residents included pain management, dermatology, pulmonary, and cardiovascular.ConclusionThere was no change in frequency of types or total interventions found in this analysis, although there was an increased frequency of advanced interventions detected in the second and third quarter. A unique learning experience for pharmacy residents was successfully implemented in an underserved, ambulatory setting.