In this study, a high correlation between anxiety, depression, and psychological stress with symptoms of RAS and OLP has been observed.

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Our research is based on oral cavity pigmentation caused by melanocytes. From my medical experience, pigmented lesions may originate from endogenous or exogenous causes. It is a known fact that human papilloma virus is a type of virus that has more than 100 species that is likely to develop cervical cancer. They manifest in various forms such as papillary hyperplasia and squamous epithelium of the oral mucosa.In a pilot study we conducted, a control group composed of 30 patients who have pigmentation of melanocytes in the form of lesion in the oral cavity underwent cytological smear biopsy test using Polymerase Chain Reaction (PCR) technique from the area of pigmentation. The results revealed that 68% of the subjects have the presence of HPV 16 with the presence of koilocytes. However, 14% of the subjects who have pigmented lesions do not have a single type of HPV but rather with pigmented melanocytes changes with normal epithelium layer. In addition, 14% of the subjects with pigmented changes did not have a single type of HPV but rather pigmented melanocytes changes with normal epithelium layer. This pilot study also revealed that 18% of the subjects with pigmented melanocytes lesions have pathological changes in the oral cavity. Therefore in conclusion, based on the pilot study the presence of the human papilloma virus is not the only cause for the presence of hyperplastic, papillomatosis lesions but also the emergence of other pathological changes in the oral cavity.