Dental caries or tooth decay is a multifactorial noncommunicable disease affecting worldwide. All age groups get affected but children and adolescences are at high risk. The main causative agent for the initiation of the process is Streptococcus mutans whereas; Lactobacillus acidophilus helps to form deep cavitations. Immunology of the oral cavity plays a vital role in eliminating the dental caries development. So, targeting the initiation process by caries vaccines will serve the purpose of preventing the process effectively.