Autism refers a wide range of conditions and the most prominent are challenges with social skills, repetitive behaviors, speech disturbances. By now, it is known that there is no one type of autism, but there are many of them which are caused by genetic factors and environmental influences. Sometimes autism is called autism spectrum disorders which reflect the wide variation in challenges and strengths possessed by each person with autism (e.g., gastrointestinal disorders, seizures, sleep disturbances, attention deficit and hyperactivity disorders, anxiety etc.). Around one third of all people with autism remain nonverbal and have an intellectual disability. This condition can be detected as early as 18 months, but the most obvious signs tend to appear between 2 and 3 years of age. Only early intervention in those patients can improve outcomes. There are no many articles published regarding laboratory findings in autism patients. By performing holistic approach in patient healing, we also face autistic children in everyday practice. In this paper we represented case of twins suffering from autism. We found that both of them had elevation of free triiodothyronine, oxytocin, osteocalcin, and basophils. We found that vitamin D level in both twins was lower than recommended. Further research in this field is necessary to reveal whether these findings are causal factors for autism or are an effect of the disease.

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Introduction: The medical test for autism is not clearly defined. Diagnosis is based on observation of behavior and educational and psychological testing, as well as medical and laboratory analyses of various specialties. Since symptoms of autism vary, pathways leading to diagnosis are also different. It is important to know that autism is not one disorder with a unique cause. Autism is most likely the cause of combinations of genetic risk factors with risk factors from the environment. In addition to common behavioral changes, we can expect epilepsy, gastrointestinal disorders, food intolerance, sleep disorders, and sensory integration disorders. Aims: to reveal the importance of multidisciplinary and holistic approach in the diagnosis of autism, the spectrum of autistic behavior of children and medical comorbidity, with the aim of creating integrative therapy and rehabilitation by personalized holistic multidisciplinary treatment. Methods: Multidisciplinary holistic diagnostic approach to health assessment was used in 21 patients with diagnosis of autism. In the health assessment, medical, integrative procedures, laboratory analyses were used. The results were statistically processed and analyzed. Result: The protocol enrolled 21 children in the "Dunjić holistic practice". All children came with diagnosis of autism. The youngest child was 3 years old and the oldest 16 years old. Distribution by experiment was in favor of male children 95%. In 65% of subjects, there were some kind of allergies, 14.2% autoimmune diseases, epilepsy in 9.5%, developmental disorders at 19.0%. Laboratory tests show different results and deviations from normal values, thyroid gland disorders TSH and T3, fT3, hyperprolactinemia results in 23.5%, increased oxytocin at 14.2%, osteocalcin in 28.5% of subjects. Viral infections of CMV, EBV and Herpes zoster were recorded at 9.5%. Conclusion: Holistic protocol in diagnosis and treatment of autism plays a significant role in the multidisciplinary therapeutic treatment. Integrative approach and procedures achieve homeostasis and internal potential for success and behavioral and medical therapy. It is necessary to do research projects on some laboratory analyses that can be indicators of an early stage of autism. Early intervention has always been the key to healing in the highest percentage.