Arch Dis Child 2012;97(Suppl 2):A1-A539 A35 Abstracts (95% CI 6.8-16.1%)] were referred to specialized hospitals and 6 [3.5% (95% CI 1.6-7.5%)] discontinued treatment. Conclusion Children with severe pneumonia with SAM could be treated safely and effectively on a day-care basis at established daycare clinics, similar to hospital management, if required logistic support is available. Background and aims Smoking in pregnancy significantly increases the risk of preterm birth and fetal growth restriction. Pregnant women are encouraged to quit smoking. Smoking in general is discouraged by antismoking laws. In the present study, we describe trends in smoking in pregnancy in the Netherlands for 2001-2010. Methods National surveys in 2001, 2002, 2003, 2005, 2007, and 2010. In well baby clinics, questionnaires were handed out to mothers with infants ≤ 6 months. Results Out of a total number of 28,720 questionnaires, 16,358 (57%) were returned. Between 2001 and 2010, prevalence of smoking in pregnancy dropped by half; from 13.0% in 2001 to 6.3% in 2010 (P trend < 0.001). The odds of being a smoker was 6.3 (95%CI 5.3-7.4) for mothers with a low education level, and 3.0 (95% CI 2.5-3.5) for mothers with a medium education level, as compared to mothers with high education level. Independently of their educational level, mothers smoked on average five cigarettes per day while pregnant. TRENDSWe .3% of Dutch pregnant women were smokers, exposing about 11,000 unborn children per year to significantly increased health risks.

Familial thrombocytosis (FT) is a hereditary disorder probably involving the regulation of megakaryopoiesis. This report is the first documented case of FT in infancy. The clinical course was complicated by a leukaemoid reaction which lasted for several months, in combination with failure to thrive and hepatosplenomegaly. At the age of 5 years the patient, with the exception of thrombocytosis, is healthy and without medication.