Glomeruloid microvascular proliferation (GMP) in breast cancer independently adversely affected survival (relative risk 1.9, 95% CI: 1.2 -3.0), particularly among women who received adjuvant chemotherapy (10-year survival 27 vs 69%, P ¼ 0.0003), and was significantly associated with p53 overexpression and BRCA1 germline mutations. The presence of GMP may influence treatment decisions.
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