Blood groups are specific to individuals and are important laboratory investigations in transfusion medicine, tissue transplants and genetic disputes. They exhibit similar serological and physiological characteristics and are inherited according to specific pattern. Thus it was chosen to assess the blood group's awareness among the Omani people during the period of 2012-2016.The required information was collected from designed questionnaires that include several variables and based on similar previously conducted studies in different parts of the world. All the participants appeared to be healthy and educated. A total of 1800 questionnaires have been distributed in six different regions (willayates) in Oman. Nearly equal number of males and females were participated in the study.The results show that blood group O+ is the dominant blood group (49.1%), followed by A+ (19.7%), B+ (17.5) and AB+ (4.7%). In addition, ABO negative groups were only reported in one region and represented a total of 0.7%, although the blood group of 8.3% of the participant was not determined.In the present investigation, the majority of the participants seem to be familiar with the blood and its constituents and all of them were found aware of the blood donation, possible diseases transmitted by blood transfusion and the use of the donated blood. In addition, the majority (72%) were seemed familiar with the hereditary blood disorders. However, the association of the ABO blood groups with serious diseases reported in various studies was difficult to be assessed. All the findings are illustrated in a table and histograms using Microsoft Excel programs and the important, relevant, issues are discussed.