The risk of delayed bleeding after EMR of large colorectal lesions is 3.7%. We developed a risk scoring system based on 6 factors that determined the risk for delayed bleeding (receiver operating characteristic curve, 0.77). The factors most strongly associated with delayed bleeding were right-sided lesions, aspirin use, and mucosal defects not closed by hemoclips. Patients considered to be high risk (score, 8-10) had a 40% probability of delayed bleeding.

*No differences in the incidence of infection or other events 500 mg bid (3 days) 200 mg iv (1 dose) • Infection after EUS-FNA is low • The use of antibiotic prophylaxis is conflicting Antibiotic Prophylaxis is Not Needed for EUS-guided FNA of Pancreatic Cystic Lesions: a Clinical Trial Results: • Non-inferiority multicenter clinical trial 226 iv (1 dose) bid (3 days) 112 ciprofloxacin 0 (0%) 2 (1.78%) 6 (5.4%) Infection Fever Other events 114 placebo 1 (0.87%) 2 (1.76%) 8 (7%)

A second ERCP after failure of initial biliary cannulation following precut appears to be safe and effective. A second ERCP should be delayed at least 4 days if feasible.