Background: Trypanosoma cruzi is subjected to hyperosmotic stress during its life cycle. Results: The recovery from hyperosmotic stress involves the function of an aquaporin, amino acid accumulation, polyphosphate synthesis, and global gene regulation.
Conclusion:The response to hyperosmotic stress is different from that observed in mammalian cells or yeasts. Significance: Learning the mechanism of osmoregulation is important for finding new drug targets.
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