Inherent safety and control properties of a reactive distillation column for the production of tetraethoxysilane are compared with those of a conventional process based in a reactordistillation column. The preliminary design of the reactive distillation column and the analysis of total annual cost and environmental indicator were obtained previously [Sańchez-Ramı ́rez et al. Ind. Eng. Chem. Res. 2018, 57, 5024−5034]. The control properties of the sequences considered were obtained by using the singular value decomposition technique and Nyquist criteria. A complementary closed-loop study using PI controller was carried out. The pairing of the variables in the control loops was carried out by the RGA technique. Process risk quantification was determined through hazard and operability study. The results indicate that reactive distillation columns seem a more appropriated technology for tetraethoxysilane production since its economic and control properties surpass those present by the conventional reaction separation process. Moreover, if the required purity for TEOS is between 98.5% and 99 wt % the profit of the process increases. Even though the inherent safe for the conventional process is slightly better, that difference is not high enough for comparative purposes.