X = Cl or Br; EWG1, EWG2 = electron withdrow group, one-pot reaction, 29 examples, yields from moderate to high, gram scale-up potential confirmed.

A one‐pot, four‐component reaction was developed for the synthesis of indolizines from pyridines, α‐halide carbonyl compounds, primary amines, and maleic anhydride. The key step in this reaction involved the copper‐catalyzed aerobic oxidative aromatization of a tetrahydrogen–indolizine intermediate. Oxygen gas was employed as a clean oxidant to facilitate the catalytic process. Notably, this transformation used readily available starting materials, exhibited broad substrate scope, was easy to handle, and required mild reaction conditions.