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In the spring of 1968 we conducted a series of pilot experiments on acute marijuana intoxication in human subjects. The study was not undertaken to prove or disprove popularly held convictions about rnarijuana as an intoxicant, to compare it with other drugs, or to introduce our own opinions. Our concern was simply to collect some long overdue pharmacological data. In this article we describe the primitive state of knowledge of the drug, the research problems encountered in designing a replicable study, and the results of our investigations.Marijuana is a crude preparation of flowering tops, leaves, seeds, and stems of female plants of Indian hemp Carznahis sativa L.; it is usually "

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