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To delineate factors that might increase the risk of thromboembolic events in patients on estrogen therapy for prostatic carcinoma a study was undertaken of various coagulation parameters. A correlation was demonstrated between advanced stages of prostatic carcinoma and depression of the serum antithrombin III activity. The addition of estrogen therapy resulted in further depression. Since low levels of serum antithrombin III activity have been associated with thrombosis this observation may have clinical relevance.

RESULTS: From 9/74 t o 9/77 a t o t a l o f 637 f u l l t e r m IDDM weighi n g a t l e a s t 2268 g were d e l i v e r e d . U s i n g t h e c r i t e r i a p r e v i o u s l : r e p o r t e d , t h e s e v e r i t y o f n e o n a t a l d r u g w i t h d r a w a l was assessed: 89% (5641637) had minor t o m i l d (MM) and 12% (731637) moderate tl severe (MS) w i t h d r a w a l . Two p e r c e n t (141637) were l a t e r r e p o r t e d t o have d i e d o f SIDS. A s i g n i f i c a n t l y h i g h e r number o f i n f a n t s w i t h MS (6173) d i e d o f SIDS compared t o t h o s e w i t h MM w i t h d r a w a l (8/564), X2=9.060, pc0.01. Those who d i e d had no s i g n i f i c a n t med. i c a l problems d u r i n g t h e n e o n a t a l p e r i o d . A l l d i e d between 4-16 weeks of age: 57% i n Winter, 21% i n Summer and 21% i n t h e F a l l . CONCLUSION:1) The frequency o f SIDS i s h i g h e r among IDDM comp a r e d t o t h e g e n e r a l p o p u l a t i o n . 2) A s i g n i f i c a n t l y h i g h e r i n c idence o f i n f a n t s w i t h MS w i t h d r a w a l d i e d from SIDS compared t o t h o s e who had l e s s e r degrees o f w i t h d r a w a l . 3) Since t h e r e i s a c o r r e l a t i o n between m a t e r n a l methadone dose and s e v e r i t y o f neon a t a l w i t h d r a w a l ( J P e d i a t , A p r i 1 / 7 6 ) , t h e use of l o w methadone dosage d u r i n g pregnancy i s s t r o n g l y recommended. PHARMACOKINETICS OF AMIKACIN I N CHILDREN WITH MALIG-NANCIES. Thomas Cleary, L a r r y K. P i c k e r i n g , Steven J. C u l b e r t , W i l l i a m Kramer, Steve Kohl, S t u a r t F e l dEys (Spon. b y R. Rodney Howell). The Univ. o f Tex.Med. School, D e~t . I n f . D i s . & P e d i a t r . . The Univ. of Tex. Svstern Canc. ~t r .,' Dept. P e d i a t r . , The ~n i v . o f Houston, Dept. -Pharm., Houston, Texas. Amikacin i s an aminoglycoside a n t i b i o t i c t h a t i s e f f e c t i v e a g a i n s t gram n e g a t i v e b a c i l l i which a r e r e s i s t a n t t o o t h e r aminoglycoside a n t i b i o t i c s . S i x and 8 hour serum c o n c e n t r a t i o n s were 1.27f1.26 and 0.6420.92 ~g / m l , r e s p e c t i v e l y .The t% was +43.8 minutes and t h e t o t a l c l e a r a n c e was 133t43 ml/min/1.73The A 9% i n a c t i v a t i o n o f a m i k a c i n o c c u r r e d when i n c u b a t e d i n normaldonor s e r a a t 3 7 O~ f o r 72 hours w i t h v a r y i n g c o n c e n t r a t i o n s of t i c a r c i l l i n .Due t o t h e r a p i d r e n a l c l e a r a n c e and s h o r t h a l f l i f e o f a m i k a c i n i n these c h i l d r e n , t h e c u r r e n t l y recommended dose o f amikacin s h o u l d be i n c r e a s e d and t h e frequency of a d m i n i s t r a t i o n shortened.as a primary,drug-related effect of maternal to fetal t r a n s f e r o f morphine s u l f a t e ( M S ) o r whether fetal responses a r e r e l a t e d to a l t e r e d maternal physiology.Four non-pregnant and 4 pregnant ewes were studied. A continuous intravenous ( I V)i...

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