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mask induced acne) in health care professionals of tertiary care hospitals of Lahore during COVID-19 Pandemic.

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Acne fulminans (AF) is a severe form of inflammatory acne, characterized by an abrupt explosive flare of multiple ulceronecrotic lesions, which can be associated with systemic symptoms. 1 We report the first case of therapy-refractory AF successfully treated with apremilast, and discuss the benefits of this medication.A 15-year-old-adolescent with personal history of overweight and acne conglobata was started on isotretinoin 0.4 mg/kg/day. Six weeks later, he presented at the emergency department with a sudden worsening of his acne with numerous painful papules, pustules, and hemorrhagic nodules with crusts, widely distributed over his back and chest (Figure 1A). He associated fever, mild diffuse myalgias and

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