Oral lichen planus (OLP) is a chronic inflammatory and immune-mediated disease affecting the oral mucosa. OLP presents with asymptomatic, lacelike white stripes and/or symptomatic red, ulcerated mucous membranes. Eating,...

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A combination of several methods was used to localize the exchangeable GTP-binding site in the a-,@tubu-lin heterodimer: (i) direct photoaffinity labeling with [IX-~~P]GTP, (ii) specific labeling of a-and @-tubulin by tyrosylation and phosphorylation, respectively, and (iii) immunoprecipitation with specific monoclonal antibodies. Direct evidence was obtained that GTP binds exclusively to j& and not a-tubulins.