Brain death induces inflammation evidenced by the up-regulation of TNF in serum and pancreatic tissue. Blocking the expression of key inflammatory mediators in brain-dead donors should be evaluated as a new approach to improve the outcomes of islet transplantation.
Chronic Hepatitis C relapse after liver transplantation can lead to graft failure
within a short time period. The high efficacy and good safety profile of
direct-acting antivirals has led to consensual recommendations for using
interferon-free treatment after liver transplantation. However, pegylated
interferon may still be required for genotype 3 non-responders. We treated a
liver graft recipient with grade 1 fibrosis in the biopsy with daclatasvir and
sofosbuvir for 12 weeks. He did not respond and progressed to grade 3 fibrosis.
Lacking other options, we obtained a sustained virological response with
pegylated interferon, ribavirin and sofosbuvir for 12 weeks. The combination of
pegylated interferon, ribavirin and sofosbuvir is a viable option after the
failure of direct acting antivirals in economically disadvantaged countries.
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